PEDIATRICS Vol. 64 No. 3 September 1979, pp. 287-291
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lerman, S. J.
Right arrow Articles by Brunken, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lerman, S. J.
Right arrow Articles by Brunken, J. M.

Nasopharyngeal Carriage of Antibiotic-Resistant Haemophilus influenzae in Healthy Children

Stephen J. Lerman MD1, Jon C. Kucera MS1, and Jan M. Brunken RN1

1 Departments of Pediatrics and Medical Microbiology, College of Medicine, University of Nebraska, Omaha

We selected 16 schools representing a broad socioeconomic cross-section of metropolitan Omaha and obtained nasopharyngeal cultures for Haemophilus influenzae from 1,084 healthy 4- to 7-year-old children. We found that 34.2% of the children carried nontypable strains and 2.0% carried type b strains. Carriage rates were not influenced by recent illness, family size, or number of people sharing a bedroom.

The prevalence of ampicillin-resistant H influenzae in the sample population was 0.9% for nontypable strains and 0.4% for type b strains; it was not significantly different in the group of children who had recently used beta-lactam antibiotics. One child carried a nontypable strain which was resistant to both chloramphenicol and tetracycline, the first chloramphenicol-resistant H influenzae detected in Omaha.

A survey of healthy children may be a useful method for projecting a community's risk of disease caused by ampicillin-resistant H influenzae. Among the nasopharyngeal isolates from healthy children, 2.7% of nontypable strains and 18.2% of type b strains were resistant to ampicillin (P < .01). During the same five-month period in Omaha, clinical failure in the treatment of otitis media with ampicillin was uncommon and four (20.0%) of 20 cases of H influenzae type b bacteremia and meningitis were caused by ampicillin-resistant organisms.

Submitted on December 8, 1978
Accepted on January 15, 1979




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. P. Jia, J. N. Kline, A. Penisten, M. A. Apicella, T. L. Gioannini, J. Weiss, and P. B. McCray Jr.
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L428 - L437.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. D. Starner, W. E. Swords, M. A. Apicella, and P. B. McCray Jr.
Susceptibility of Nontypeable Haemophilus influenzae to Human {beta}-Defensins Is Influenced by Lipooligosaccharide Acylation
Infect. Immun., September 1, 2002; 70(9): 5287 - 5289.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
R. A. Seaton, D. T. Steinke, G. Phillips, T. MacDonald, and P. G. Davey
Community antibiotic therapy, hospitalization and subsequent respiratory tract isolation of Haemophilus influenzae resistant to amoxycillin: a nested case-control study
J. Antimicrob. Chemother., August 1, 2000; 46(2): 307 - 309.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
A. Friedman and G. Fleisher
Meningitis: Update of Recommendations for the Neonate
Clinical Pediatrics, June 1, 1980; 19(6): 395 - 397.
[Abstract] [PDF]