PEDIATRICS Vol. 64 No. 2 August 1979, pp. 238-241
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Symptomatic Arteriovenous Malformation in Infants Less Than 6 Months of Age

Richard P. Knudson MD1 and Errol R. Alden MD1

1 Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington

The symptomatology and sequelae of symptomatic system arteriovenous (A-V) malformations in children less than 6 months old make an early diagnosis possible and early treatment mandatory. A group of 156 infants with systemic A-V malformations involving the CNS (81 infants), liver (61 infants), and lungs (14 infants) were studied to compare symptoms, diagnosis, treatment, and outcome. Congestive heart failure was present in 67% of the patients with CNS A-V malformations. Mortality among the patients with CNS A-V fistulas was 64%. Of those patients with hepatic A-V malformations 67% had abdominal masses, 48% congestive heart failure, and 55% died. Pulmonary A-V malformations presented with congestive heart failure 57%, cyanosis 43%, and resulted in a 43% mortality. Early combined medical and surgical therapy offered the best chance for a successful outcome.

Submitted on December 13, 1978
Accepted on February 5, 1979




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