PEDIATRICS Vol. 64 No. 1 July 1979, pp. 50-52
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Negative Effects of Oral Fatty Acid Supplementation on Sweat Chloride in Cystic Fibrosis

John D. Lloyd-Still MD1, Stuart H. Simon MD1, Hans U. Wessel MD1, and Lewis E. Gibson MD1

1 Department of Pediatrics, Northwestern University, and Department of Pediatrics, Loyola University, Chicago

Essential fatty acid supplementation with oral safflower oil (1 gm/kg/day) to 11 cystic fibrosis patients (aged 6 months to 14 years) for one year produced no significant change in sweat chloride concentration (mEq/liter) or sweat rate (gm/min/m2). Addition of vitamin E (10 mg/kg/day) to the safflower oil had no effect on sweat chloride concentration or rate compared to placebo. No clinical improvement could be detected compared to a control group. These results do not support previous reports of the effects of fatty acid supplementation on sweat electrolyte concentrations in cystic fibrosis.

Submitted on September 8, 1978
Accepted on November 7, 1978