PEDIATRICS Vol. 63 No. 6 June 1979, pp. 847-850
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The Effects of Stimulant Medication on the Growth of Hyperkinetic Children

Alex F. Roche M.D., Ph.D.1, Ronald S. Lipman Ph. D.1, John E. Overall Ph.D.1, and Wellington Hung M.D.1

1 Fels Research Institute, Wright State University School of Medicine, Yellow Springs, Ohio; National Institute of Mental Health, Rockeville, Maryland; University of Texas, Galveston; and the Chidren's Hospital National Medical Center, Washington, D. c.

This article reviews the literature on possible growth-suppressing effects of stimulant medications in the long-term treatment of children with the hyperkinetic behavior syndrome. The evidence clearly indicates a temporary retardation in the rate of growth in weight and suggests a temporary slowing of growth in stature, but no effect on adult stature or weight. This temporary effect on growth is present during the first few years of treatent and seems related to drug dosage and to the presence or absence of drug holidays. These conclusions relate specifically to treatment during the prepubertal period; little is known of the growthrelated effects of treatment extending through pubescence.

Submitted on December 9, 1977
Accepted on February 20, 1978




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