PEDIATRICS Vol. 63 No. 5 May 1979, pp. 788-790
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Inheritance of Uncomplicated Hypospadias

Lyman A. Page M.D.1

1 Department of Pediatrics, Webber Hospital, Biddeford, Maine

Isolated first-degree hypospadias in three generations of one family and in two generations of two families is reported and the literature reviewed. Pedigree information suggests autosomal-dominant, sex-limited inheritance in these cases although other inheritance patterns are possible. Mendelian transmission of hypospadias may be more frequent than commonly believed and implies that the abnormality is potentially definable in molecular terms.

Submitted on April 17, 1978
Accepted on August 10, 1978