PEDIATRICS Vol. 63 No. 5 May 1979, pp. 754-756
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Long-Term Use of Propranolol, Ibuprofen, and Spironolactone in the Management of Bartter's Syndrome

Robert J. Cunningham M.D.1, Ben H. Brouhard M.D.2, Michael Berger M.D.2, Tom Petrusick M.D.2, and Luther B. Travis M.D.2

1 Departusent of Pediatrics, Division of Pediatric Nephrology and Diabetes, The University of Texas Medical Branch, Galveston
2 Department of Pediatrics, Division of Pediatric Nephrology and Diabetes, The University of Texas Medical Branch, Galveston

This report concerns two patients wter'sth Barter's syndrome who were treated with propranolol, spironolactone, and potassium supplements. When ibuprofen was added to this regimen, potassium supplements were no longer required. In both patients, plasma renin activity decreased, plasma volumes increased, and a "catch-up" in linear growth ensued. This report confirms others that indicate prostaglandin synthetase inhibitors are a useful adjunct in the therapy of Bartter's syndrome.

Submitted on June 23, 1978
Accepted on September 5, 1978