PEDIATRICS Vol. 63 No. 5 May 1979, pp. 731-735
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lanes, R.
Right arrow Articles by Lee, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lanes, R.
Right arrow Articles by Lee, P. A.

Sustained Effect of Human Growth Hormone Therapy on Children With Intrauterine Growth Retardation

Roberto Lanes M.D.1, Leslie P. Plotnick M.D.1, and Peter A. Lee Ph.D., M.D.1

1 Division of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, The Johns Hopkins University, Baltimore

Previous studies have not clarified whether human growth hormone (HGH) therapy can significantly increase the height of patients with intrauterine growth retardation (IUGR). To determine whether the initial increase in growth rate is sustained through subsequent treatiment, 19 prepubertal patients who had IUGR were treated with HGH Ten of them received a second treatment course. Growth rates (in centimeters per year) were 4.8 ± 1.4 ( mean ± SD) for the pretreatment period, 7.6 ± 2.3 for the first treatment period, 4.2 ± 2.5 for the interval between treatments, 5.9 ± 1.4 for the second treatment period, and 4.3 ± 2.6 for the posttreatment period. Growth rates for the two treatment periods were significantly greater than for the periods before, interval between, and posttreatment. Height expressed as the number of standard deviations below the mean for age increased significantly between the onset of treatment and the most recent measurement. These data indicate that HGH has a sustained positive effect on increasing growth rates in children with IUGR, although the magnitude of the effect may decrease with further treatment. Furthermore, we suggest that it is worthwhile to treat patients who have IUGR with HGH for prolonged periods of time, if supplies exceed those necessary to treat children with growth hormone deficiency.

Submitted on July 20, 1978
Accepted on August 24, 1978




This article has been cited by other articles:


Home page
 PediatricsHome page
F. de Zegher and A. Hokken-Koelega
Growth Hormone Therapy for Children Born Small for Gestational Age: Height Gain Is Less Dose Dependent Over the Long Term Than Over the Short Term
Pediatrics, April 1, 2005; 115(4): e458 - e462.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. de Zegher, K. Albertsson-Wikland, H. A. Wollmann, P. Chatelain, J.-L. Chaussain, A. Löfström, B. Jonsson, and R. G. Rosenfeld
Growth Hormone Treatment of Short Children Born Small for Gestational Age: Growth Responses with Continuous and Discontinuous Regimens Over 6 Years
J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2816 - 2821.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Lanes
Growth Hormone Treatment in Patients with Intrauterine Growth Retardation
J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1345a - 1346.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. d. Zegher, I. Francois, m. van helvoirt, and g. van den berghe
Small as Fetus and Short as Child: From Endogenous to Exogenous Growth Hormone
J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2021 - 2026.
[Full Text] [PDF]