PEDIATRICS Vol. 63 No. 5 May 1979, pp. 724-730
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Apnea Recordings of Healthy Infants at 40, 44, and 52 Weeks Postconception

Israel M. Stein M.D.1, Ann White R.N.1, Joseph L. Kennedy Jr. M.D.1, Roberta L. Merisalo R.N.1, Harvey Chernoff M.D.1, and Jeffrey B. Gould M.D.1

1 Clinical Research Division, Clinical Data, Inc., Brookline, Massachusetts; and the Boston Perinatal Center, St. Margaret's Hospital for Women; the Department of Pediatrics, Boston University School of Medicine; and the Departmemnt of Pediatrics, Tufts University School of Medicine, Boston

A total of 129 recordings of the respiratory activity of 46 normal full-term infants were obtained continuously for 24 hours in the hospital nursery at 3 days of life and in the home environment at 4 weeks and 12 weeks after birth. The pediatric pneumogram (PPG) technique, an impedance method, was used. Pneumogram data over longer than 16 hours was obtained on 77% of infants monitored. No infants experienced apnea longer than 15 seconds in duration at 40 and 44 weeks postconception. or greater than 11 seconds at 52 weeks postconception. Twenty-four hour plots of hourly apnea frequency revealed a marked variability, with evidence of clustering of apneic episodes during periods of reported sleep. Longest apnea time and hourly frequency of apneic episodes were highly correlated.

Submitted on July 17, 1978
Accepted on September 22, 1978




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