PEDIATRICS Vol. 63 No. 4 April 1979, pp. 606-608
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Repeated Naloxone Administration for Morphine Overdose in a 1-Month-Old Infant

Alan E. Gober M.D.1, Gregory L. Kearns B.S.1, Robert A. Yokel Ph.D.1, and Larry Danziger Pharm.D.1

1 University of Cincinnati Department of Pediatrics, the Drug and Poison lnformation Center, and the Children's Hospital Medical Center, Cincinnati

Repeated injections of naloxone hydrochloride, a pure narcotic antagonist, were administered to a 3,320-gm 4-week-old boy for treatment of an accidental morphine overdose. The infant received frequent naloxone hydrochloride injections (0.2 mg per injection) during the first 12 hours of therapy to reverse morphine-induced apnea, hypothermia, and flaccidity. A cumulative dose of 2.73 mg of naloxone hydrochloride (0.822 mg/kg) was administered over 27 hours without apparent adverse effect or evidence of toxicity.

Submitted on August 18, 1978




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[Abstract] [PDF]