PEDIATRICS Vol. 63 No. 3 March 1979, pp. 504
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Letter To The Editor

H. Halkin M.D.1

1 Clinical Pharmacology Unit, The Chaim Sheba Medical Center, Tel-Aviv University Medical School, Tel-Hashomer, Israel

Excessive serum digoxin concentrations do not establish the diagnosis of digitalis intoxication but certainly mark the subgroup of digitalis-treated patients who are at high risk of intoxication. True, seven of ten infants tolerated high serum concentrations without adverse effect, but intoxication was nonetheless highly prevalent (30%) among these infants.

The choice of the 2 ng/ml level was not arbitrary but rather represents the well-established lower limit of the toxic range in adults. Our findings support the statement that it is of the same significance in the agc group studied.