PEDIATRICS Vol. 63 No. 3 March 1979, pp. 483-485
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A Decongestant-Antihistamine Mixture in the Prevention of Otitis Media in Children With Colds

John E. Randall M.D.1 and J. Owen Hendley M.D.1

1 Departments of Pediatrics, Canandaigua Medical Group P.C., Canandaigua, New York, and University of Virginia Medical School, Charlottesville, Virginia

One hundred four preschool-age patients in a private pediatric practice were treated prospectively during colds with either decongestant-antihistamine or placebo to determine if the decongestant-antthistamine mixture was effective in the prevention of otitis media. Each child received a standard dosage of the study medicine according to a double-blind, crossover design. Otitis media was diagnosed on the basis of clinical criteria.

Fifteen (6.4%) of 234 colds treated with placebo and 14 (5.8%) of 241 colds treated with the study drug were followed by otitis. The decongestant-antihistamine mixture was not useful in preventing development of otitis media in children with colds.

Submitted on October 25, 1978
Accepted on December 12, 1978




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