PEDIATRICS Vol. 63 No. 3 March 1979, pp. 414-415
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Ketotic Hypoglycemia and Hypopituitarism

William B. Lorentz Jr. M.D.1

1 Department of Pediatrics, Bowman Gray School of Medicine Winston-Salem, NC 27103

A 5-year-old girl had hypoglycemia and was of short stature. Studies of pituitary function demonstrated combined growth hormone and adrenocorticotropic hormone (ACTH) deficiency. She was shown to have ketotic hypoglycemia. In contrast to patients previously reported with hypopituitarism and ketotic hypoglycemia, she had no deficiency of gluconeogenic substrate. Serum levels of alanine and other gluconeogenic amino acids were normal during fasting and hypoglycemia.

These studies suggest that inadequate gluconeogenic precursors are not the cause of her ketotic hypoglycemia. Ketotic hypoglycemia in association with hypopituitarism may be secondary to multiple biochemical defects.




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