PEDIATRICS Vol. 63 No. 2 February 1979, pp. 256-260
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barkin, R. M.
Right arrow Articles by Pichichero, M. E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barkin, R. M.
Right arrow Articles by Pichichero, M. E

Diphtheria-Pertussis-Tetanus Vaccine: Reactogenicity of Commercial Products

Roger M. Barkin M.D., M.P.H.1 and Michael E Pichichero M.D.1

1 Department of Pediatrics, University of Colorado Medical Center, Denver

Parents from four practices were surveyed to ascertain reactions of children to diphtheria-pertussis-tetanus (DPT) vaccine in the 48 hours after immunization. Vaccines were administered according to current recommendations. Responses were scored in three categories: temperature, behavioral changes, and local reactions. Questionnaires were returned by 1,232 (84.9%) patients. Only 7.0% reported no reaction, while 336 (27.3%) reported mild, 722 (58.6%) moderate, and 88 (7.1%) severe reactions. Over 50% experienced temperatures of at least 100 F, and 80% noted behavioral changes; 72.2% had local reactions. No encephalitis, seizures, or hospitalizations were reported. Reactogenicity was similar for the five immunizations of the recommended series and the two manufacturers evaluated. Reported reactions in the control group were significantly lower than in the study group. These reaction rates underline the need to reevaluate present DPT vaccines.

Submitted on July 24, 1978
Accepted on November 27, 1978




This article has been cited by other articles:


Home page
 PediatricsHome page
M. E. Pichichero, K. M. Edwards, E. L. Anderson, M. B. Rennels, J. A. Englund, D. E. Yerg, W. C. Blackwelder, D. L. Jansen, and B. D. Meade
Safety and Immunogenicity of Six Acellular Pertussis Vaccines and One Whole-Cell Pertussis Vaccine Given as a Fifth Dose in Four- to Six-Year-Old Children
Pediatrics, January 1, 2000; 105(1): e11 - e11.
[Abstract] [Full Text] [PDF]