PEDIATRICS Vol. 63 No. 2 February 1979, pp. 242-246
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Sickle Cell Anemia in Two White American Children: Essential Laboratory Criteria for Diagnosis

Peter A. Noronha M.D.1 and George R. Honig M.D., Ph.D.1

1 Division of Hematology, Children's Memorial Hospital, and the Department of Pediatrics. Northwestern University School of Medicine, Chicago

A number of hematologic disorders share diagnostic and clinical features of sickle cell anemia but have significantly different genetic implications and prognosis. Because of these differences, the establishment of a precise diagnosis is essential for the child in whom any form of sickle cell disease is identified. To illustrate the requirements for a definitive laboratory diagnosis of sickle cell anemia, this report presents the approach to establishing this diagnosis in two white American patients. From a review of the literature, these patients appear to be the only white Americans with sickle cell anemia in whom this diagnosis has been unequivocally established.

Submitted on April 24, 1978
Accepted on June 6, 1978




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