PEDIATRICS Vol. 63 No. 1 January 1979, pp. 80-87
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Thymic Deficiency in Down's Syndrome

Stanley Levin M.B., Ch.B.1, Menahem Schlesinger M.D.1, Zaev Handzel M.D.1, Thalia Hahn M.Sc.1, Yehudit Altman B.Sc.1, Bernard Czernobilsky M.D.1, and Jochanan Boss M.D.1

1 John Askin, Laboratories of the Pediatric Research Department, and the Department of Pathology, kaplan Hospital Rehovot, lsrael, and the Department of Pathology, Hebrew University-Hadassah Medical School, Jerusalem

Children with Down's syndrome (DS) often have small and abnormal thymuses, with lymphocyte depletion, diminution of the cortex, and loss of corticomedullary demarcation—a picture resembling thymic involution. Besides this, they have markedly enlarged Hassall's corpuscles, some surrounded by a sheath of lymphocytes. Patients with DS are known to have increased numbers of respiratory infections; they also have a higher incidence of lymphaic leukemia than do individuals who do not have DS. Studies of cell-mediated (thymic-dependent) immunity demonstrate that children with DS have both diminished numbers of T cells as well as functional deficiency of these cells.

Submitted on February 21, 1978
Accepted on May 11, 1978




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