PEDIATRICS Vol. 63 No. 1 January 1979, pp. 44-46
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Successful Treatment of Juvenile Chronic Granulocytic Leukemia With Marrow Transplantation

Jean E. Sanders M.D.1, C. Dean Buckner M.D.1, Patricia Stewart M.D.1, and E. Donnall Thomas M.D.1

1 Fred Hutchinson Cancer Research Center, Seattle, and the Departments of Medicine and Pediatrics, University of Washington School of Medicine, Seattle

A 46-month-old boy with juvenile chronic granulocytic leukemia was treated intensively with hydroxyurea dimethyl myleran, cyclophosphamide, and total body irradiation. He then received a marrow transplant from an HL-A matched brother. Thirty-two months after the transplantation, he is hematologically normal and remains disease free on no-maintenance therapy. The successful outcome of this case suggests that a bone marrow transplant for any patient with a suitable histocompatible donor should be considered in the treatment of this disease.

Submitted on April 8, 1978
Accepted on May 31, 1978




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