PEDIATRICS Vol. 62 No. 5 November 1978, pp. 811-818
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The Use of Furosemide in the Treatment of Edema in infants and Children

Mary Allen Engle M.D.1, John E. Lewy M.D.1, Peter R. Lewy M.D.1, and Jack Metcoff M.D.1

1 New York Hospital-Cornell Medical Center; Children's Memorial Hospital, Chicago; and the University of Oklahoma, Health Science Center, Oklahoma City

One hundred thirty-seven courses of furosemide therapy were given to 106 hospitalized pediatric patients with salt and water retention associated with cardiac or renal disease. The diuretic was effective and safe in the pediatric age group when administered acutely as a parenteral medication and over a long-term course by the oral route in the doses and at the time intervals used in this study. On the basis of each kilogram of body weight, the infants with edema as a result of cardiac failure and the children with edema secondary to renal disease responded equally well to furosemide therapy.

Submitted on February 2, 1978
Accepted on April 5, 1978