PEDIATRICS Vol. 62 No. 4 October 1978, pp. 620-621
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Group B Streptococcal and Pneumococcal Sepsis in Newborn Infants: The Role of Pneumococcal Antibody

Gerald W. Fischer M.D.1, James W. Bass M.D.1, George H. Lowell M.D.2, and Martin H. Crumrine Ph.D.3

1 Department of Pediatrics, School of Medicine, Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda, MD 20014
2 Walter Reed Army Institute of Research, Washington, DC 20012
3 Madigan Army Medical Center, Tacoma, WA 98431

The article by Bortolussi et al. on pneumococcal septicemia and meningitis in the neonat (Pediatrics 60:352, September 1977) was of great interest to us, since we have been analyzing the effect of antibody directed against Streptococcus pneumoniae on group B Streptococcus type III. We have recently shown (unpublished data) that antibody directed against S. pneumoniae type 14 precipitates the hot hydrochloric acid-extracted polysaccharide antigen of group B Streptococcus type III. Further studies have shown that this antibody is opsonic for group B Streptococcus type III in an in vitro bactericidal assay and protective in a suckling rat model of group B Streptococcus type III sepsis.1




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Type III Group B Streptococcal Polysaccharide Induces Antibodies That Cross-React with Streptococcus pneumoniae Type 14
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