PEDIATRICS Vol. 62 No. 4 October 1978, pp. 478-487
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Hypercholesterolemia and Hyper-agr-Lipoproteinemia in Schoolchildren

Charles J. Glueck M.D.1, Kathe Kelly B.Sc.1, Margot J. Mellies M.D.1, Peter S. Gartside Ph.D.1, and Paula M. Steiner B.A.1

1 Lipid Research and General Clinical Research Centers, Departments of Medicine and Epidemiology and Biostatistics, University of Cincinnati, College of Medicine

Elevated levels of high-density lipoprotein cholesterol (C-HDL) can explain apparent hypercholesterolemia in some children, and high C-HDL levels may aggregate in families. In this study, 17 kindreds were identified by virtue of hypercholesterolemic proband children whose hypercholesterolemia was accounted for by elevated C-HDL levels. Family lipid and lipoprotein sampling revealed three-generation vertical appearance of elevated C-HDL level in two kindreds, and two-generation vertical appearance in eight additional kindreds. Since C-HDL level is inversely associated with coronary heart disease in adults, it is important to quantitate C-HDL and low-density lipoprotein cholesterol (C-LDL) in hypercholesterolemic children and to identify those with putatively reduced risk (elevated C-HDL level) or increased risk (elevated C-LDL level).

Submitted on November 21, 1977
Accepted on February 14, 1978




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 Health Educ BehavHome page
N. K. Iammarino, A. D. Weinberg, and J. D. Holcomb
The State of School Heart Health Education: A Review of the Literature
Health Educ Behav, January 1, 1980; 7(4): 298 - 320.
[Abstract] [PDF]