PEDIATRICS Vol. 62 No. 4 October 1978, pp. 468-477
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Parent-Child Associations at Upper and Lower Ranges of Plasma Cholesterol and Triglyceride Levels

John A. Morrison Ph.D.1, Kathe A. Kelly B.Sc.1, Margot J. Mellies M.D.1, Ido deGroot M.P.H.1, and Charles J. Glueck M.D.1

1 Lipid Research Clinic and the General Clinical Research Center, University of Cincinnati College of Medicine

This study examines the hypothesis that children of parents who have very high and very low levels of cholesterol and triglyceride are more likely than other children to have cholesterol and triglyceride levels at the same ends of the distribution as their parents. For each lipid studied (cholesterol and triglyceride), 1,944 households were separated into three categories: "low," "intermediate," and "high," based on parental fasting plasma levels and using the fifth (low) and 95th (high) percentiles of the parental distributions. The children were first categorized according to the classification of their parents and then further classified on the basis of their own levels, again using the fifth and 95th percentiles as cutoff points. The agreement between parental and child classifications was then measured. Children from high-cholesterol-level households were 2.7 times more likely than children from the total pediatric population to have cholesterol levels above 205 mg/dl, the pediatric 95th percentile, (P < .01). Children from high-triglyceride-level households were 2.1 times more likely than children from the general pediatric population to have elevated triglyceride levels (P < .01).

By the simple expedient of focusing on parental cholesterol and triglyceride levels, which are commonly quantitated in adults, a pediatric sample was identified that contained significant numbers of hypercholesterolemic and hypertriglyceridemic children.

Submitted on October 19, 1977
Accepted on December 27, 1977




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