PEDIATRICS Vol. 62 No. 4 October 1978, pp. 460-464
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pearlman, M. A.
Right arrow Articles by Horoupian, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pearlman, M. A.
Right arrow Articles by Horoupian, D. S.

Absence of Kernicterus in Low-Birth-Weight Infants From 1971 Through 1976: Comparison With Findings in 1966 and 1967

Mark A. Pearlman M.D.1, Lawrence M. Gartner M.D.1, Kwang-sun Lee M.D.1, Rachel Morecki M.D.1, and Dikran S. Horoupian M.D., F.R.C.P.(C)1

1 Division of Neonatology, Department of Pediatrics, and the Department of Pathology, The Rose F. Kennedy Center and the Bronx Municipal Hospital Center, Albert Einstein College of Medicine, Bronx, New York

A review of 34 autopsied infants weighing 2,250 gm or less who died on the third to seventh days of life during the six-year period from 1971 through 1976 failed to reveal any cases of kernicterus. This contrasts with an incidence of 64% in low-birth-weight infants selected in the same manner from the same neonatal intensive care unit-premature center during the period 1966 and 1967. The 34 infants in the 1971-1976 series were not significantly different with regard to their birth weights, Apgar scores, perinatal complications, or pathologic findings, other than their lack of kernicterus, from the 14 infants in the 1966-1967 series. The only significant difference between these two groups of infants was a lower mean peak serum bilirubin concentration in the 1971-1976 series, corresponding with the establishment in 1970 of a more aggressive policy of exchange transfusion and phototherapy. The prevention of excessive hyperbilirubinemia along with the development of more sophisticated intensive care of the neonate in recent years may be responsible for the elimination of kernicterus in the 1971-1976 series of infants.

Submitted on December 1, 1977
Accepted on March 23, 1978




This article has been cited by other articles:


Home page
 PediatricsHome page
S. L. Merhar and D. L. Gilbert
Clinical (Video) Findings and Cerebrospinal Fluid Neurotransmitters in 2 Children With Severe Chronic Bilirubin Encephalopathy, Including a Former Preterm Infant Without Marked Hyperbilirubinemia
Pediatrics, November 1, 2005; 116(5): 1226 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. Govaert, M. Lequin, R. Swarte, S. Robben, R. De Coo, N. Weisglas-Kuperus, Y. De Rijke, M. Sinaasappel, and J. Barkovich
Changes in Globus Pallidus With (Pre)Term Kernicterus
Pediatrics, December 1, 2003; 112(6): 1256 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
J F Watchko and M J Maisels
Jaundice in low birthweight infants: pathobiology and outcome
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F455 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M J Maisels and J F Watchko
Treatment of jaundice in low birthweight infants
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F459 - 463.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
A. F. Robertson, W. B. Karp, H. C. Davis, W. Zack Catterton, and C. Bunyapen
Predicting the Need for Exchange Transfusion in Newborn Infants: A Comparison of Five Methods
Clinical Pediatrics, August 1, 1983; 22(8): 533 - 536.
[Abstract] [PDF]