PEDIATRICS Vol. 62 No. 4 October 1978, pp. 454-459
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tyler, D. C.
Right arrow Articles by Cheney, F. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tyler, D. C.
Right arrow Articles by Cheney, F. W.

Mechanical and Chemical Damage to Lung Tissue Caused by Meconium Aspiration

Donald C. Tyler M.D.1, Janet Murphy M.B., Ch.B.1, and Frederick W. Cheney M.D.1

1 Departments of Anesthesiology and Pediatrics, University of Washington, Seattle

We investigated the effects of meconium on the lungs of an adult rabbit model to distinguish between mechanical obstruction of airways and chemical pneumonitis. After the rabbits were anesthetized and intubated, 20% human meconium in saline was instilled into the trachea. Arterial and mixed venous blood gases, functional residual capacity, cardiac output, vascular pressures, calculated venous admixture, and pulmonary vascular resistance were measured. Sections of affected lung tissue were examined microscopically. The results were consistent with an early mechanical obstruction of airways with gradual development of chemical pneumonitis over 48 hours.

Submitted on October 14, 1977
Accepted on January 11, 1978




This article has been cited by other articles:


Home page
 PediatricsHome page
K. Okazaki, M. Kondo, M. Kato, R. Kakinuma, A. Nishida, M. Noda, K. Taniguchi, and H. Kimura
Serum Cytokine and Chemokine Profiles in Neonates With Meconium Aspiration Syndrome
Pediatrics, April 1, 2008; 121(4): e748 - e753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. Khan, O. Elidemir, C. E. Epstein, K. P. Lally, H. Xue, M. Blackburn, G. L. Larsen, and G. N. Colasurdo
Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a murine model
Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L785 - L790.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. ALMAAS, B. ROBERTSON, B. LINDERHOLM, E. LUNDBERG, O. D. SAUGSTAD, and A. MOEN
Reversal of Meconium Inhibition of Pulmonary Surfactant by Ferric Chloride, Copper Chloride, and Acetic Acid
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1789 - 1794.
[Abstract] [Full Text]