PEDIATRICS Vol. 62 No. 1 July 1978, pp. 47-51
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Diagnostic Dilemmas of Wilson's Disease: Diagnosis and Treatment

Steven L. Werlin M.D.1, Richard J. Grand M.D.1, Jay A. Perman M.D.1, and John B. Watkins M.D.1

1 Department of Pediatrics, Harvard Medical School, and the Division of Gastroenterology, Department of Medicine, Children's Hospital Medical Center, Boston

Wilson's disease, an autosomal recessive disorder of copper metabolism, may defy diagnosis in children The classical triad of Kayser-Fleischer rings, neurologic dysfunction, and hypoceruloplasminemia may be absent. Patients may be seen initially with acute or chronic hepatitis, hemolytic anemia, or neurologic dysfunction. Guidelines are presented for diagnosis of Wilson's disease based on a review of 25 pediatric and adolescent patients. A high index of suspicion is necessary so that therapy with penicillamine may be begun before irreversible liver or neurologic damage occurs. The prognosis is excellent when diagnosis and treatment are established early.

Submitted on December 13, 1976
Accepted on September 15, 1977




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