PEDIATRICS Vol. 61 No. 6 June 1978, pp. 864-866
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Hepatic Injury in a Child Caused by Trimethoprim-Sulfamethoxazole

David K. Stevenson M.D.1, Dennis L. Christie M.D.1, and Joel E. Haas M.D.1

1 Departments of Pediatrics and Pathology, Children's Orthopedic Hospital and Medical Center, University of Washington School of Medicine, and the Mason Clinic, Seattle

Trimethoprim-sulfamethoxazole was given to a 16-year-old boy as prophylaxis for a urinary tract infection. He developed severe cholestatic hepatitis 41 days after administration of the drug. A liver biopsy specimen showed a mixed inflammatory infiltrate in the portal triads and prominent bile stasis. The clinical course in this patient supports the concept of an indirect hypersensitivity reaction to sulfamethoxazole.

Submitted on July 21, 1977
Accepted on November 4, 1977




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F. K. Ghishan
Trimethoprim-sulfamethoxazole-induced Intrahepatic Cholestasis
Clinical Pediatrics, March 1, 1983; 22(3): 212 - 214.
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