PEDIATRICS Vol. 61 No. 1 January 1978, pp. 91-93
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Nephrogenic Diabetes Insipidus Due to Demethylchlortetracycline Hydrochloride in a Child

Arnold L. London M.D.1, Norman J. Siegel M.D.1, Joseph H. Zelson M.D.1, and John P. Hayslett M.D.1

1 Departments of Pediatrics and Medicine, Yale University School of Medicine, New Haven, Connecticut

Nephrogenic diabetes insipidus occurred in a 7-year-old child who had received a high dose of demethylchlortetracycline hydrochloride (DMC). The patient had a relatively elevated urinary sodium concentration in addition to isosthenuria. The nephrogenic diabetes insipidus was completely reversible within one month after cessation of DMC administration.

Submitted on July 29, 1977
Accepted on September 23, 1977