PEDIATRICS Vol. 61 No. 1 January 1978, pp. 68-72
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Acetaminophen: Report of an Unusual Poisoning

Jay M. Aren M.D.1, Malcolm H. Rourk Jr. M.D.1, and Corry D. Sibrack M.D.1

1 Department of Pediatrics, Duke University Medical Center, Durham, North Carolina

This is a report of an unusual acetaminophen poisoning in a 3-year-old girl who, three days after the ingestion of an estimated thirty-five 325-mg tablets of acetaminophen, had the highest levels of hepatic enzymes ever recorded at Duke Hospital. Although she was only moderately ill with an enlarged liver, she was discharged from the hospital on the seventh day in good condition. The liver enzyme levels returned to normal when last assessed, 50 days after ingestion. The importance of determining acetaminophen Plasma concentration at different times to evaluate more precisely the plasma half-life is discussed, along with the current suggested therapy now being recommended for acetaminophen poisoning.

Submitted on February 25, 1977
Accepted on August 31, 1977




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S. M. Swetnam and A. L. Florman
Probable Acetaminophen Toxicity in an 18-month-old Infant Due to Repeated Overdosing
Clinical Pediatrics, February 1, 1984; 23(2): 104 - 105.
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