PEDIATRICS Vol. 61 No. 1 January 1978, pp. 57-61
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Candida albicans Meningitis in a Premature Neonate Successfully Treated With 5-Fluorocytosine and Amphotericin B: A Case Report and Review of the Literature

Lawrence D. Lilien M.D.1, Rajam S. Ramamurthy M.D.1, and Rosita S. Pildes M.D.1

1 Departments of Pediatrics, Cook County Hospital, The Chicago Medical School, and The University of Illinois College of Medicine, Chicago

Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor sucking. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.

Submitted on June 21, 1977
Accepted on June 28, 1977




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