PEDIATRICS Vol. 60 No. 5 November 1977, pp. 753-754
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Oxygen and retrolental fibroplasia: The questions persist

Désenchantés Les Chermignonards

The Cooperative Study of Retrolental Fibroplasia (RLF) conducted in 1953 and 19541 was notable for successfully utilizing a newly developed tool, the randomized clinical trial, in finding an answer to an urgent clinical question. It is timely to recall the details of the question that was addressed by that pioneering effort: "Will curtailment2 of supplemental oxygen reduce the risk of RLF without an unreasonable increase in mortality in infants weighing 1.5 kg or less at birth and who survive longer than 48 hours?" Although the results supported an affirmative reply to the specific question posed, a number of additional questions of considerable practical importance emerged from analyses of the large body of data collected in the study.




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