PEDIATRICS Vol. 59 No. 6 June 1977, pp. 998-1005
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The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model

Dale L. Phelps M.D.1 and Arthur L. Rosenbaum M.D.1

1 Departments of Pediatrics and Ophthalmology, University of California at Los Angeles School of Medicine

The effect of tocopherol (vitalnin E) on oxygen-induced retinopathy was studied in 75 kittens following the development of a 12-point scoring system to quantitate the degree of retinopathy seen at three weeks. The tocopherol was found to be beneficial when given daily from the day of birth (P < .0001) with oxygen exposures of two to three days (79% F1O2) beginning on day 3. Caution is urged in applying these data to humans because (1) hepatosplenomegaly was noted in the treated animals, and (2) the kitten model of oxygen-induced retinopathy is not entirely satisfactory,

Submitted on November 24, 1976
Accepted on January 11, 1977