PEDIATRICS Vol. 59 No. 6 June 1977, pp. 995-997
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Vitamin E and Neonatal Hemolysis

Steven J. Gross M.D.1, Stephen A. Landaw M.D.1, and Frank A. Oski M.D.1

1 Departments of Pediatrics and Medicine, State University of New York, Upstate Medical Center, and the Veterans Administration Hospital, Syracuse, New York

A study was designed to determine if the presence of vitamin E deficiency during the first week of life played a contributory role in the shortened red cell life span observed in the premature infant. Carboxyhemoglobin values were used as an index of hemolysis. Ten infants received vitamin E administered intramuscularly in a total dose of 125 mg/kg during days 3 to 7 of life; ten infants served as controls. The mean percent carboxyhemoglobin level fell significantly from day 3 to day 8 in the treated group (1.08% to 0.78%) whereas the mean value remained unchanged at 0.96% in the control group. The administration of vitamin E appears to reduce but not eliminate the accelerated red cell destruction that characterizes the preterm infant.

Submitted on December 8, 1976
Accepted on January 27, 1977


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