PEDIATRICS Vol. 59 No. 6 June 1977, pp. 902-906
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Serum Concentration and Serum Half-Life of Digoxin in Premature and Mature Newborns

Dieter Lang M.D.1 and Götz von Bernuth M.D.1

1 Department of Pediatrics, University of Ulm, Ulm, Germany

Serum concentrations and half-life times of digoxin were determined in ten mature and nine premature newborns. Median serum digoxin concentration was 2.3 ng/ml (1.2 to 3.5 ng/ml) in mature newborns and 2.4 ng/ml (1.5 to 4.5 ng/ml) in premature newborns. Median serum digoxin half-life was 35 hours (17 to 52 hours) in mature newborns and 57 hours (38 to 88 hours) in premature newborns. The difference in serum digoxin half-life between the two groups is statistically significant. The relatively long serum digoxin half-life in premature newborns is probably due to immature renal function in this group. The data emphasize the need for cautious digoxin administration, especially in premature infants.

Submitted on July 9, 1976
Accepted on October 26, 1976




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