PEDIATRICS Vol. 59 No. 2 February 1977, pp. 219-223
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brouhard, B. H.
Right arrow Articles by Carvajal, H. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brouhard, B. H.
Right arrow Articles by Carvajal, H. F.

Simultaneous Iothalamate, Creatinine, and Urea Clearances in Children With Renal Disease

Ben H. Brouhard M.D.1, Luther B. Travis M.D.1, Robert J. Cunningham III M.D.1, Michael Berger M.D.1, and Hugo F. Carvajal M.D.1

1 Department of Pediatrics, Division of Nephrology, University of Texas Medical Branch, Galveston

Glomerular filtration rate (GFR) is often used to evaluate and manage patients with renal disease. Few studies in children have compared accurate estimations of GFR (clearance of inulin and/or iothalamate) with the clearance of creatinine which, because of simplicity, has been used as an approximation of GFR. At reduced levels of GFR, studies in adults suggest that the mean of the creatinine and urea clearances closely approximate the GFR. The present investigation shows that the clearance of creatinine approximates the GFR at normal levels; however, at reduced levels the creatinine clearance and the mean of the creatinine and urea clearances both overestimate the GFR as measured by iothalamate. The clearance of creatinine remains a useful clinical tool if its limitations at low levels of GFR are realized.

Submitted on February 10, 1976
Accepted on April 19, 1976