PEDIATRICS Vol. 59 No. 1 January 1977, pp. 115-117
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Hypersensitivity to Methylphenidate and Dextroamphetamine: A Report of Two Cases

Jeffrey Sverd M.D.1, Maria J. Hurwic Ph.D.1, Oliver David M.D.1, and Bertrand G. Winsberg M.D.1

1 Child Psychiatric Evaluation Research Unit, New York State Department of Mental Hygiene, Division of Child Psychiatry, Downstate Medical Center, Brooklyn, New York

Among the adverse reactions to methylphenidate and dextroamphetamine are those which strongly suggest an allergic basis. With regard to methylphenidate, most reports of allergic reactions in children have involved the skin. Thus, Rothschild and Nichol1 reported the case of a 5-year-old girl who developed conjunctivitis and experienced formication while receiving 5 mg of methylphenidate twice daily. Lytton and Knobel2 described a case of urticaria following methylphenidate treatment; and Gross and Wilson3 noted the occurrence of a skin rash in a child. There are also indications that methlyphenidate allergy may occur among adults. For example, Weil4 reported on a 73-year-old woman who developed exfoliative dermatitis while on that medication.




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