PEDIATRICS Vol. 58 No. 6 December 1976, pp. 885-892
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Phosphaturia in Thalassemia

P. Lapatsanis M.D.1, S. Sbyrakis M.D.1, C. Vretos Ch.B.1, A. Karaklis M.D.1, and S. Doxiadis M.D.1

1 Institute of Child Health, Athens, Greece

Thirteen phosphorus balances were performed in four thalassemic children aged 6 to 10 years. No correlation was found between phosphorus intake and serum level or between phosphorus intake and net absorption. There was a positive correlation among daily phosphorus intake, net absorption, and 24-hour urinary excretion. The 24-hour urinary excretion level was higher than net absorption, indicating that these children have normal phosphorus absorption but abnormally high renal phosphaturia, which leads to a deficiency of phosphorus. A strongly positive correlation was found between values for hemoglobin and serum alkaline phosphatase. In the thalassemic patients with hemoglobin levels ge7.5 gm/100 ml, the serum alkaline phosphatase values were ge15 King-Armstrong units, suggesting normal osteoblast function.

Submitted on May 12, 1975
Accepted on September 29, 1975