PEDIATRICS Vol. 58 No. 5 November 1976, pp. 776
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Serum T3 and T4 Levels in Sick Children

J. N. Carter 1, J. M. Corcoran 1, C. J. Eastman 1, L. Lazarus 1, and M. O'Halloran 2

1 Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales, Australia
2 Royal Alexandra Hospital for Children, Sydney, New South Wales, Australia

We have reported that most adults with severe, chronic, nonthyroidal illnesses (i.e., sick euthyroid patients) have significantly decreased circulating levels of triiodothyronine (T3) and thyroxine (T4), whilst the thyrotropin (TSH) levels are not elevated.1 The T3 levels are usually reduced into the hypothyroid range, whilst the T4 levels generally remain within the normal range. The patients in that study were aged from 21 to 84 years.

We have recently concluded a study of circulating thyroid hormone levels in children of various ages and have found that the mean levels of both T3 and T4 are higher than in adults.