PEDIATRICS Vol. 58 No. 5 November 1976, pp. 774-775
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Inheritance of Cryptorchidism

Iraj Rezvani M.D.1, Kenneth R. Rettig M.D.1, and Angelo M. DiGeorge M.D.1

1 Department of Pediatrics, Temple University School of Medicine, and St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19133

The majority of instances of undescended testes occur sporadically, but cryptorchidism in more than one member of a family is not rare in our experience despite the paucity of published reports. Occurrence of cryptorchidism among siblings has been reported by several investigators.1-3 Charny and Wolgin described left-sided undescended testes in a father and his two sons4; Scorer and Farrington also have observed several instances where both father and son have had cryptorchidism.5 The genetics and hereditary pattern of isolated cryptorchidism is not clear at this time, although many genetic syndromes associated with cryptorchidism are known.6