PEDIATRICS Vol. 58 No. 4 October 1976, pp. 561-563
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Hemolytic-Uremic Syndrome: Absence of Circulating Endotoxin

P. M. V. Van Wieringen M.D.1, L. A. H. Monnens M.D.1, J. A. J. M. Bakkeren 1, and Biochem D. 1

1 Department of Pediatrics, University of Nijmegen, Radboud Ziekenhuis, Nijmegen, The Netherlands

In children with hemolytic-uremic syndrome endotoxin determinations were carried out in the peripheral circulation in order to get evidence for the hypothetical role of endotoxin in the pathogenesis of the disease. For this purpose the Limulus test was used to determine endotoxin activity in 16 patients with hemolytic-uremic syndrome. In the plasma of these patients no endotoxin could be detected above the lower detection limit of 100 pg/ml, although in all patients with septicemia due to gram-negative bacilli the test was positive.

Submitted on October 28, 1975
Accepted on December 4, 1975




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S. O'Regan, P. Robitaille, J.-G. Mongeau, and B. McLaughlin
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Clinical Pediatrics, February 1, 1980; 19(2): 125 - 127.
[Abstract] [PDF]