PEDIATRICS Vol. 58 No. 4 October 1976, pp. 505-507
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Urogenital Tract Abnormalities in Sons of Women Treated With Diethylstilbestrol

Brian E. Henderson M.D.1, Barbara Benton R.N.1, Malcolm Cosgrove M.D.1, Joyce Baptista M.A.1, James Aldrich M.S.1, Duane Townsend M.D.1, William Hart M.D.1, and Thomas M. Mack M.D.1

1 Departments of Pathology, Community Medicine and Public Health, and Surgery (Urology), University of Southern California School of Medicine, Los Angeles

Since in utero exposure to diethylstilbestrol (DES) is known to cause abnormalities of the female genital tract later in life, exposed male offspring were located, surveyed by mail, and compared with unexposed male offspring from the same period and medical practices. The exposed and unexposed respondents appeared comparable and did not differ in their response to most medical questions. However, a larger proportion of exposed than of unexposed boys had experienced problems in passing urine (12.9% vs. 1.8%; P = .0003) and abnormalities of the penile urethra (4.4% vs. 0%; P = .017).

Submitted on December 15, 1975
Accepted on March 11, 1976




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