PEDIATRICS Vol. 58 No. 3 September 1976, pp. 463
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Aminophylline, a Weak Bilirubin Displacer

Rolf Brodersen Ph.D.1 and Signe Andersen 1

1 Institute of Medical Biochemistry, University of Aarhus, DK-8000 Aarhus C. Denmark

We have examined the bilirubin-displacing effect of aminophylline, using the peroxidase method.1 It was found that the free bilirubin concentration is increased by 1% for each 2 mg of aminophylline per liter of blood plasma. The results are practically independent of varying concentrations of albumin and fatty acid, within the usual limits. Control experiments indicated that aminophylline does not interfere with the reagents of the test and does not form a bilirubin complex in significant amounts.