PEDIATRICS Vol. 58 No. 3 September 1976, pp. 432-435
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levy, G.
Right arrow Articles by Houston, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levy, G.
Right arrow Articles by Houston, J. B.

Effect of Activated Charcoal on Acetaminophen Absorption

Gerhard Levy Pharm.D.1 and J. Brian Houston Ph.D.1

1 Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo

Acetaminophen intoxication can cause hepatic, renal, and myocardial necrosis which is often fatal. These lesions develop very rapidly, perhaps during the first pass of the drug through the liver. In case of acute ingestion of an overdose it is therefore essential to employ measures for reducing the absorption of acetaminophen. The effect of activated charcoal on acetaminophen absorption by normal volunteers was determined as a function of the dose of charcoal, the dosage form of acetaminophen, and the charcoal-to-acetaminophen dose ratio. The results indicate that activated charcoal can be an effective antidote for acute acetaminophen intoxication, if administered promptly and in sufficient quantity.

Submitted on November 28, 1975
Accepted on November 17, 1975




This article has been cited by other articles:


Home page
 CirculationHome page
Part 10: First Aid
Circulation, November 29, 2005; 112(22_suppl): III-115 - III-125.
[Full Text] [PDF]

Home page
 PediatricsHome page
S. E. Haun, J. E. Segeleon, and R. M. Ward
Acetaminophen Toxicity in Children
Pediatrics, July 1, 2002; 110(1): 197 - 198.
[Full Text] [PDF]