PEDIATRICS Vol. 58 No. 2 August 1976, pp. 211-217
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Cholesterol Among Children of Men With Myocardial Infarction

Charles H. Hennekens M.D.1, Mary Jane Jesse M.D.1, Barbara E. Klein M.D.1, Janet E. Gourley B.S.N.1, and Sidney Blumenthal M.D.1

1 Departments of Pediatrics and Epidemiology and Public Health, University of Miami School of Medicine, Miami, Florida, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

Plasma cholesterol levels were obtained on 90 children of 39 men with premature myocardial infarction and 86 children of 39 healthy men. The mean cholesterol among children of affected men (195.1 mg/100 ml) was higher than among children of healthy men (176.6 mg/100 ml) (P = .009). Higher mean levels were demonstrable at each of nine age groups from 1 to 21 years (P = .004). Levels greater than 230 mg/100 ml were found in 16.7% of children of affected fathers and 4.7% of children of healthy fathers, a ratio of 3.6 to 1 (P = .01). These findings are compatible with the hypothesis that elevated childhood cholesterol level offers a mechanism whereby family history predicts coronary disease.

A dip in cholesterol during adolescence, a finding that varies with population studied, was demonstrable among children of both affected and healthy men.

Submitted on August 18, 1975
Accepted on December 8, 1975




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