PEDIATRICS Vol. 57 No. 5 May 1976, pp. 794-797
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Vitamin D Toxicity After Dieting in Hypoparathyroidism

Matthew H. Connors M.D.1, Bagher M. Sheikholislam M.D.1, and Julian J. Irias M.D.1

1 Department of Pediatrics, School of Medicine, University of California, Davis, California

Attempts at management of idiopathic hypoparathyroidism with vitamin D have led to various reports of resistance to therapy,1 different responses to vitamin D preparations,2 and unexplained toxicity.3 We report a patient with idiopathic hypoparathyroidism who was persistently hypocalcemic during ten months of treatment with vitamin D, 150,000 units/day. After voluntary weight reduction he became hypercalcemic on the same dose of vitamin D. We believe that the toxicity in this instance was due to release of stored vitamin D into the circulation.

CASE REPORT

The patient was referred to the hospital at 12frac12 years of age because of intracranial calcifications noted on roentgenograms obtained for the evaluation of sinusitis.




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