PEDIATRICS Vol. 57 No. 3 March 1976, pp. 363-371
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Insulin Responses During Catch-up Growth of Infants Who Were Small for Gestational Age

Eleanor Colle M.D.1, David Schiff M.D., Ph.D.1, Gail Andrew M.D.1, Charles B. Bauer M.D.1, and Pamela Fitzhardinge M.D.1

1 Montreal Children's Hospital-McGill University Research Institute, Montreal, Canada

Growth characteristics of 15 full-term infants, selected because of weights more than 2 SD below the mean for gestational age, are described. The response to an intravenous injection of glucose was utilized to measure the insulin response of the infants at 6 months.

Infants small for gestational age grow at a faster rate than appropriate-for-age infants during the first six months of life. There was a positive correlation between the growth velocity of the period and insulin release and a negative correlation between growth velocity and birth length. There was no correlation between these variables and increases in weight during the same period.

Growth velocity during catch-up growth is related to the degree of preceding retardation but insulin may play a permissive role.

Submitted on May 7, 1975
Accepted on July 25, 1975




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