PEDIATRICS Vol. 57 No. 2 February 1976, pp. 197-200
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Developmental Effects of Seizures: Role of Malnutrition

Claude G. Wasterlain M.D.1

1 Department of Neurology, Cornell University Medical College, New York, New York

Eighty-eight rats were paired at birth according to sex and weight. One member of each pair received two electroconvulsive seizures a day during the neonatal period (days 2 to 11). Access of its control littermate to the mother was restricted so that the body weights of any two paired rats never diverged by more than 2 gm on any day of life, and were usually within one half gram of each other. This guaranteed that the nutritional status of seizuretreated and control animals was similar throughout development.

On day 30 of life, seizure-treated rats had smaller brains (-56 mg, P < .05) and reduced numbers of brain cells (-13.106, P < .05) compared to their control littermates. It was concluded that the reduction of brain DNA brought about by neonatal seizures was not simply caused by malnutrition of seizure-treated animals.

Submitted on January 20, 1975
Accepted on June 17, 1975




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