PEDIATRICS Vol. 57 No. 1 January 1976, pp. 166
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More Questions Regarding Arginine Hydrochloride Inhalation

Ernest K. Cotton M.D.1

1 University of Colorado, Medical Center, 4200 East Ninth Avenue Denver, Colorado 80220

Dietzsch et al. have confirmed observations that we reported to the Cystic Fibrosis Research meeting in April 1968.1 In summary, we found that when the sodium ion, in the form of sodium bicarbonate or sodium hydroxide, is added to L-arginine hydrochloride an irritating solution to the airway is formed. During the discussion, Mancos suggested that the sodium transport mechanism may be additionally interferred with. Our studies indicated that cystic fibrosis patients breathing the sodium-buffered L-arginine definitely lowered their airway conductance while L-arginine buffered with the free base improved airway conductance.