PEDIATRICS Vol. 56 No. 6 December 1975, pp. 1050-1055
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Mortality From Tuberculous Meningitis Reduced by Steroid Therapy

Jorge A. Escobar M.D., M.P.H., T.M.1, Mark A. Belsey M.D., M.P.H., T.M.1, Alvaro Dueñas M.D., M.P.H., T.M.1, and Pablo Medina M.D., M.P.H.1

1 Departments of Pediatrics, Universidad del Valle, Cali, Colombia, and Tulane University, New Orleans, Louisiana, and the Department of Microbiology, Universidad del Valle, Cali, Colombia

In this study of 99 tuberculous meningitis patients from Cali, Colombia, treatment with steroids (in conjunction with antituberculous drugs) was shown to be more effective in reducing mortality than treatment with antibacterial drugs alone. Results further suggest that low dosages of steroids (1 mg/kg of prednisone daily for 30 days) are equally effective in treating the disease as high dosages (10 mg/kg of prednisone at the start of treatment, gradually reduced over a 30-day period). These results are based on sequential analysis of matched pairs, a statistical method particularly appropriate for clinical trials.

Submitted on August 8, 1975
Accepted on February 5, 1975




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