PEDIATRICS Vol. 56 No. 6 December 1975, pp. 1021-1025
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A Comparison of the Physical and Intellectual Development of Black Children With and Without Sickle-Cell ell Trait

Michael K. McCormack Ph.D.1, Sandra Scarr-Salapatek Ph.D.1, Herbert Polesky M.D.1, William Thompson B.S.1, Solomon H. Katz Ph.D.1, and William B. Barker Ph.D.1

1 Dight Institute for Human Genetics, the Institute of Child Development, the Departments of pediatrics, Genetics and Cell Biology, and Laboratory Medicine and Pathology, and the Minneapolis War memorial Blood Bank, University of Minnesota, Minneapolis, and the Departments of Anthropology and Orthodontics, W. M. Krogman Center for Research on Child Growth and Development, the Eastern Pennsylvania Psychiatric Institute, and the Graduate School of Education, University of Pennsylvania, Philadelphia

Sickle-cell trait, a condition present in 7% to 9% of the United States Black population, is usually considered to be a clinically benign condition. However, there is increasing evidence to indicate the contrary, that is, the clinical pathophysiology is variable, ranging from a benign condition in most cases to a relatively few cases of severe pathological involvement. Physical and intellectual growth measures were taken on 19 children with sickle-cell trait (12 boys and 7 girls) from a large study of Black same-sex twin pairs from Philadelphia, Pennsylvania, and compared to measures taken of a sample of normal Black children from 155 monozygotic and dizygotic same-sex twin pairs. Sickle-cell trait carriers were found to weigh less, have smaller upper arm circumference, lesser skinfold thickness, and showed less mature skeletal age, differing significantly from normal children. Sickle-cell carriers tended to score lower on four of five intellectual measures, scoring one fifth to one third of a standard deviation lower than normal children.

Submitted on April 15, 1974
Accepted on February 18, 1975




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Naghma-e-Rehan
Growth Status of Children with and without Sickle Cell Trait
Clinical Pediatrics, November 1, 1981; 20(11): 705 - 709.
[Abstract] [PDF]