PEDIATRICS Vol. 56 No. 5s November 1975, pp. 944-947
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Airway Smooth Muscle in Exercise-Induced Bronchospasm: Some Speculations

Elliott Middleton Jr. M.D.1

1 National Asthma Center, Denver, Colorado

Some possible neurophysiolal, biochemical, and pharmacological pathways affecting the state of contractility if airway smooth muscle in exercise-induced bronchospasm (EIB) are described. No unifying hypothesis can be set forth at this time. Indeed, it is likely that the heterogeneous nature of EIB is a reflection of the numerous biochemical loci in smooth muscle cells that could be affected by the various metabolic changes accompanying heavy exertion.