PEDIATRICS Vol. 56 No. 5s November 1975, pp. 937-939
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New Drug Evaluation Using Exercise-Induced Bronchospasm

Arthur C. Sprenkle M.D.1, Paul P. VanArsdel Jr. M.D.1, and C. Warren Bierman M.D.1

1 Division of Allergy and the Department of Medicine, University of Washigton School of Medicine, Seattle

Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolynlike drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind cross-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchopasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.