PEDIATRICS Vol. 56 No. 5s November 1975, pp. 856-859
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Exercise-Induced Asthma in Children With Intrinsic and Extrinsic Asthma

Peyton A. Eggleston M.D.1

1 Department of Pediatrics, University of Virginia School of Medicine, Charlottesville

The significance of intrinsic asthma as a diagnosis has been questioned since, except for the lack of evidence of allergy, there is no pathophysiologic distinction from extrinsic asthma. Following a standardized exercise stress, allergic (extrinsic) asthmatics respond with more severe asthma than do nonallergic (intrinsic) asthmatics. The incidence of significant exercise-induced asthma is greater in a group of extrinsic asthmatics than in intrinsic asthmatics. Extrinsic asthmatics show increased airway sensitivity during a significant pollen season.